When I was a post doc at Harvard one of the real treasures was the chemistry library, which had some very impressive archives as you might imagine. Amongst these was a DVD recording of a lecture that R.B. Woodward gave in 1972 following his completion of the total synthesis of vitamin B12 (along with Albert Eschenmoser). If you are into this sort of thing and have 3.5 hours to spare it is a real gem. Here is part 1:
Very close to where I work in Cambridge, there is a strange and inexplicable Potemkin village. I have worked in the same building for almost two years and did not notice it until relatively recently.
On the corner of Portland and Main St. there is a building that at first glance does not draw any attention, in retrospect quite deliberately. A few months ago I was walking by and idly ran my fingertips over the “brick” exterior, when I noticed it was covered with a veneer *painted* with windows, doors, etc.
Why the need for this faux exterior I do not understand. I have peered beneath and the true surface of the building is basically just some shabby brickwork; nothing that would obviously explain the desire to masquerade as something else. How strange!
Here is the location on Google maps:
On the topic of Viagra®, there has been a barrage of TV commercials lately, all of which are heavily tinted in blue/green. I’m wondering, is this a suggestion of the side effect of cyanopsia (“a medical term for seeing everything tinted with blue”). Hmm…
I spotted this empty blister pack of viagra tablets on the sidewalk (6x100mg, the largest dose they make). Stepped on, discarded with haste. I have no idea what sequence of events could have led to this.
As far as I’m concerned, lysine is just OK. As an overall class of molecules, amino acids are sort of bland. Slim pickens in terms of functional diversity. Not a lot of a razzle dazzle. And among the 20-22 (depending on who you ask) lysine is about as average as it gets. If there were a Yelp review for lysine I would give it 2 out of 5 stars. And yet I can think of two major movies where lysine was a critical plot element. The first dates back to my awkward middle school years: Jurassic Park invoked the “lysine contingency” as a last resort means to control unmitigated dinosaur reproduction. Clip here.
More recently, and more based in reality, the 1996 lysine price-fixing scandal was brilliantly portrayed by a hefty Matt Damon in The Informant! In this movie I enjoyed how Damon put a slight emphasis on the second syllable in lysine, opposite how I’ve always heard it.
Are there other amino acids that have been pivotal in other movies? I can’t think of too many off the top of my head. Maybe dopamine/levodopa in Awakenings is all that comes to mind.
The pages of the Sigma catalog are replete with thousands of high-quality chemical reagents. But today I stumbled upon something I hadn’t seen before: “Sewage Sludge (Mixed Origin)“. This material is not only exorbitantly expensive ($619.20 for 40g) but also backordered! Perhaps there is an unmet demand for pristine sewage sludge. Your guess is as good as mine.
This is from the GE Life Sciences handbook Gel Filtration: Principles and Methods. It is shown on page 45 with no context whatsoever, other than potential applications of their fancy technology. For non-biologists, this is a so-called gel filtration trace, which is a technique used to separate a mixture of proteins based on their size. The peaks (which range from the big sharp one at ~45 minutes to the smaller lumpy things around 20 minutes) correspond to the proteins that are present in tears. The most basic interpretation of this figure is that there are at least 6 or so proteins that make up the majority of those found in tears. But there are so many more questions!
What are these different proteins?
Whose tears were these?
How were the tears obtained? Did someone go to a funeral with a test tube and collect tears of grief? Did they stab somebody for tears of pain? Perhaps an olympic athlete donated tears of joy after winning the javelin throw.
Would the protein components of the tears be different depending on whether they are tears of joy/sorrow/pain?
Why is the buffer so salty (0.5M NaCl) and acidic (pH 5.3)? Are tear proteins only happy under salty acidic conditions?
Stephen Colbert belted out an awesome rendition of Friday on last nights Jimmy Fallon.
There is an easter egg at the 3:48 point; some weirdo in the background holding up a giant square barcodey thing (technically a QR Code). Here are some screencaps I took. I couldn’t find any online tools to parse these, it seems like the only way to read them is with an app for your mobile phone. I used QR Reader for iPhone. If you are too lazy to install and take a picture of your computer I will tell you it is a link to this website.
I was in the post office yesterday, and I noticed they have these flat-rate shipping boxes, advertised with the slogan “If it fits, it ships.” So you pay $13.95 to ship anything that will fit inside a 12″ x 12″ x 5 1/2″ box, for example. Wouldn’t it be funny to fill up one of these boxes with the densest element on the periodic table, then go to the post office and ship it?
Of course the element I speak of is osmium, which weighs in at a hefty 22.6 g/cm3. If my math is correct here, that 12″x12″x5.5″ box translates into 792 cubic inches, or 12.98 liters. Fill it up with a huge block of osmium and it would weigh 293 kilograms, or 646 pounds.
So you’d probably actually need like 6 people to lift the box. And the fact that osmium costs ~$30/gram, this little prank would cost $8.8 million to pull off. Depleted uranium might be a little more economical. It’s only 19.1g/cm3, so fill up that same box with DU and it would only weigh 546 pounds. Still pretty funny.